Custom melanoma vaccines provoke T cells

Personalized melanoma vaccines can spark a powerful immune response against unique mutations in patients’ tumors, according to early data from a first-in-humans clinical trial.

The tailor-made vaccines, given to three patients with advanced melanoma, appeared to increase the number and diversity of cancer-fighting T cells responding to the tumors. The finding is a boost to cancer immunotherapy, a treatment strategy that unleashes the immune system to seek out and destroy cancer.

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